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hemophilia meaning

Depending on the degree of the disorder present in an individual, excess bleeding may occur only after specific, predictable events (such as surgery, dental procedures, or injury), or … PO Box 8923, New Fairfield, CT 06812-8923. { bidder: 'appnexus', params: { placementId: '11654174' }}, bids: [{ bidder: 'rubicon', params: { accountId: '17282', siteId: '162036', zoneId: '776160', position: 'atf' }}, 'cap': true Those individuals who require dental work or any surgery may need to be pre-treated with an infusion of factor VIII to avoid hemorrhage. Because the skull has no room for expansion, the hemophiliac individual is at risk for brain damage due to blood taking up space and exerting pressure on the delicate brain tissue. (Males inherit one X and one Y chromosome, and therefore have only one X chromosome.). pbjs.setConfig(pbjsCfg); { bidder: 'sovrn', params: { tagid: '346688' }}, { bidder: 'openx', params: { unit: '539971079', delDomain: 'idm-d.openx.net' }}, Recently, a good deal of concern has been raised about the possibility of hemophiliacs contracting a fatal slow virus infection of the brain (, The most exciting new treatments currently being researched involve efforts to transfer new genes to hemophiliacs. Therefore, even if she receives one flawed X chromosome, she will still be capable of producing a sufficient quantity of factors VIII and IX to avoid the symptoms of hemophilia. What does 'poke' refer to in the expression 'pig in a poke'. googletag.cmd.push(function() { (800) 42-HANDI. name: "pbjs-unifiedid", { bidder: 'ix', params: { siteId: '195466', size: [728, 90] }}, Stephenson, J. { bidder: 'triplelift', params: { inventoryCode: 'Cambridge_SR' }}, Hemophilia A and B are both caused by a genetic defect present on the X chromosome. dfpSlots['houseslot_b'] = googletag.defineSlot('/2863368/houseslot', [], 'ad_houseslot_b').defineSizeMapping(mapping_houseslot_b).setTargeting('sri', '0').setTargeting('vp', 'btm').setTargeting('hp', 'center').setTargeting('ad_group', Adomik.randomAdGroup()).addService(googletag.pubads()); {code: 'ad_topslot_a', pubstack: { adUnitName: 'cdo_topslot', adUnitPath: '/2863368/topslot' }, mediaTypes: { banner: { sizes: [[300, 50], [320, 50], [320, 100]] } }, All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. { Because the trait is carried only on the X chromosome, it is called "sex-linked." { bidder: 'criteo', params: { networkId: 7100, publisherSubId: 'cdo_topslot' }}, If, however, she has a son who receives her flawed X chromosome, he will be unable to produce the right quantity of factors VIII or IX, and he will suffer some degree of hemophilia. pbjs.que = pbjs.que || []; { bidder: 'appnexus', params: { placementId: '11653860' }}, googletag.cmd.push(function() { Hemophilia A affects between one in 5,000 to one in 10,000 males in most populations. These individuals have had the unfortunate occurrence of a spontaneous mutation; meaning that in their early development, some random genetic accident befell their X chromosome, resulting in the defect causing hemophilia A or B. Can you spell these 10 commonly misspelled words? Medications or drugs that promote bleeding, such as aspirin, should be avoided. googletag.cmd = googletag.cmd || []; cmpApi: 'iab', { bidder: 'ix', params: { siteId: '555365', size: [120, 600] }}, (203) 746-6518 or (800) 999-6673. }, Patients with relatively mild disease will only require treatment in the event of injury, or to prepare for scheduled surgical or dental procedures. { bidder: 'ix', params: { siteId: '195451', size: [320, 50] }}, { bidder: 'appnexus', params: { placementId: '11654156' }}, googletag.pubads().setTargeting("sfr", "cdo_dict_english"); },{ googletag.pubads().setTargeting("cdo_l", "en"); iasLog("criterion : cdo_ei = hemophilia"); Individuals who receive factor prepared from pooled donor blood are at risk for serious infections that may be passed through blood. 'max': 3, { bidder: 'ix', params: { siteId: '555365', size: [160, 600] }}, When a blood vessel is injured in a way that causes bleeding, platelets collect over the injured area, and form a temporary plug to prevent further bleeding. googletag.pubads().addEventListener('slotRenderEnded', function(event) { if (!event.isEmpty && event.slot.renderCallback) { event.slot.renderCallback(event); } }); var mapping_leftslot = googletag.sizeMapping().addSize([1063, 0], [[120, 600], [160, 600], [300, 600]]).addSize([963, 0], [[120, 600], [160, 600]]).addSize([0, 0], []).build(); { bidder: 'triplelift', params: { inventoryCode: 'Cambridge_MidArticle' }}, Because a female child always receives two X chromosomes, she nearly always will receive at least one normal X chromosome. { bidder: 'appnexus', params: { placementId: '11654157' }}, storage: { { bidder: 'criteo', params: { networkId: 7100, publisherSubId: 'cdo_rightslot' }}, { bidder: 'openx', params: { unit: '539971081', delDomain: 'idm-d.openx.net' }}, Such individuals frequently experience spontaneous bleeding, most frequently into their joints, skin, and muscles. }); ga('set', 'dimension3', "default"); 'max': 30, 'min': 3.05, The final plug involves tightly woven fibers of a material called fibrin. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. window.__tcfapi('addEventListener', 2, function(tcData, success) { National Hemophilia Foundation. { bidder: 'pubmatic', params: { publisherId: '158679', adSlot: 'cdo_rightslot' }}]}, Hemophilia is a genetic disorder—usually inherited—of the mechanism of blood clotting. if(window.__tcfapi) { bidder: 'ix', params: { siteId: '195465', size: [300, 250] }}, { bidder: 'onemobile', params: { dcn: '8a969411017171829a5c82bb4deb000b', pos: 'cdo_topslot_728x90' }}, This classification is based on the percentage of normal factor VIII activity present: Individuals with hemophilia B have symptoms very similar to those of hemophilia A, but the deficient factor is factor IX. initAdSlotRefresher(); pbjsCfg.consentManagement = { var mapping_btmslot_a = googletag.sizeMapping().addSize([746, 0], [[300, 250], 'fluid']).addSize([0, 0], [[300, 250], [320, 50], [300, 50], 'fluid']).build(); { bidder: 'criteo', params: { networkId: 7100, publisherSubId: 'cdo_topslot' }}, These are administered intravenously (directly into the patient's veins, (Illustration by Electronic Illustrators Group.). { bidder: 'criteo', params: { networkId: 7100, publisherSubId: 'cdo_topslot' }}, { bidder: 'onemobile', params: { dcn: '8a969411017171829a5c82bb4deb000b', pos: 'cdo_btmslot_300x250' }}, Hepatitis, a severe and potentially fatal viral liver infection, may be contracted from pooled factor preparations. {code: 'ad_btmslot_a', pubstack: { adUnitName: 'cdo_btmslot', adUnitPath: '/2863368/btmslot' }, mediaTypes: { banner: { sizes: [[300, 250]] } }, {code: 'ad_btmslot_a', pubstack: { adUnitName: 'cdo_btmslot', adUnitPath: '/2863368/btmslot' }, mediaTypes: { banner: { sizes: [[300, 250]] } }, iasLog("criterion : cdo_l = en"); What are synonyms for hemophilia? dfpSlots['btmslot_a'] = googletag.defineSlot('/2863368/btmslot', [[300, 250], 'fluid'], 'ad_btmslot_a').defineSizeMapping(mapping_btmslot_a).setTargeting('sri', '0').setTargeting('vp', 'btm').setTargeting('hp', 'center').setTargeting('ad_group', Adomik.randomAdGroup()).addService(googletag.pubads()); name: "_pubcid", iasLog("setting page_url: - https://dictionary.cambridge.org/dictionary/english/hemophilia"); At least thirteen different clotting factors have been identified. By race/ethnicity, the prevalence was 13.2 cases/100,000 among white, 11.0 among African-American, and 11.5 among Hispanic males. }, https://medical-dictionary.thefreedictionary.com/hemophilia. Inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhages, spontaneous or traumatic, because of a defect in the blood-coagulating mechanism. "loggedIn": false bids: [{ bidder: 'rubicon', params: { accountId: '17282', siteId: '162036', zoneId: '1666926', position: 'btf' }}, { bidder: 'appnexus', params: { placementId: '11654208' }}, This type of hemophilia is also known as Christmas disease. { bidder: 'criteo', params: { networkId: 7100, publisherSubId: 'cdo_rightslot' }}, Patients with more severe disease will require regular treatment to avoid spontaneous bleeding. Hemophilia is a rare disorder in which your blood doesn't clot normally because it lacks sufficient blood-clotting proteins (clotting factors). Usage explanations of natural written and spoken English, 0 && stateHdr.searchDesk ? }; { bidder: 'openx', params: { unit: '539971080', delDomain: 'idm-d.openx.net' }},

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